Molecular Basis of Disease

The objective of this course is to introduce GSBS graduate students to approaches used to understand the molecular causes of representative diseases and application of such knowledge toward the design and implementation of rational therapies. The course focuses on variety of diseases, including neurodegenerative, cardiovascular, and metabolic diseases. Interspersed among these topics will be guest speakers who will discuss specific aspects of the drug design process and novel approaches to therapy, including gene-, RNA-, and cell-based interventions. Class discussions will also help prepare students to participate effectively in team-oriented translational science. Students will write a short NIH-style research proposal addressing a disease mechanism or therapy development of interest and defend the proposal during the last two weeks of class.